Oncotarget A mutation-specific, single-arm, phase 2 study of dovitinib

Oncotarget Volume 11 Issue 14 reported that of 80 patients enrolled, common tumors included gastrointestinal stromal tumors, colorectal cancer, and ovarian cancer.

The most common treatment-related adverse events were fatigue, diarrhea, nausea, and vomiting.

In this heterogeneous patient population, the safety profile was acceptable for dovitinib therapy.

A subset of patients with RTK pathway-activated tumors experienced clinical benefit.

Dr. Matthew H. Taylor from the Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA said, "Receptor tyrosine kinases (RTKs), including vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and the proto-oncogene cKIT play multiple roles in tumor growth, development, and survival."

"Receptor tyrosine kinases (RTKs), including vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and the proto-oncogene cKIT play multiple roles in tumor growth, development, and survival."

- Dr. Matthew H. Taylor, Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University

Receptor tyrosine kinases, including vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, and the proto-oncogene cKIT play multiple roles in tumor growth, development, and survival.

In the clinic, dovitinib has demonstrated promising activity in a number of cancers, including as a single agent in gastrointestinal stromal tumors and in combination with fulvestrant in advanced breast cancer.

Figure 1: Clinical benefit per tumor type cohort^a. ^aOnly tumor types with at least 4 patients are included. ^bPatients for whom clinical benefit was non-evaluable are included under "no clinical benefit" as follows: ACC n = 1; Colorectal cancer n = 2; Gastrointestinal stromal tumor n = 3; HNSCC n = 3; NSCLC adenocarcinoma n = 1; ovarian n = 3; thymus n = 3. Abbreviations: ACC, adenoid cystic carcinoma; HNSCC, head and neck squamous cell carcinoma; NSCLC, non-small cell lung cancer; PR, partial response; SD, stable disease.

The purpose of this tumor histology-agnostic study was to determine whether dovitinib treatment demonstrated sufficient efficacy in select RTK pathway-activated cancers to support additional studies.

The Taylor Research Team concluded in their Oncotarget Research Article, "dovitinib therapy was well tolerated in this heavily pretreated patient population and clinical benefit was observed in a subset of patients following dovitinib treatment. Future studies may provide additional insights into the role of the tumor genomic background in response to dovitinib therapy."

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DOI - https://doi.org/10.18632/oncotarget.27530

Full text - https://www.oncotarget.com/article/27530/text/

Correspondence to - Matthew H. Taylor - taylmatt@ohsu.edu

Keywords - advanced malignancies, basket trial, dovitinib, histology-agnostic, mutation-specific

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