Dealing with Runaway Metastatic Disease

“Metastatic disease remains a major issue in daily practice in oncology because the outcome is still often fatal.”

BUFFALO, NY - August 7, 2024 – A new editorial paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, “How to deal with runaway metastatic disease?”

In this new editorial, Justine Paris and Guilhem Bousquet from Université Paris Cité, Université Sorbonne Paris Nord, and APHP, Hôpital Avicenne, Oncologie médical, discussed how their research team have shown that PROM2 is a predictive biomarker of distant metastases and shorter survival among patients with stage III melanomas.

More recently, in a large preclinical study using cancer cell lines and various mouse models of human melanomas, the researchers also demonstrated that the runaway metastatic process is closely linked to PROM2 overexpression, through the increase of epithelial-to-mesenchymal transition (EMT) marker expression and ferroptosis resistance.

“We report two critical findings: (i) these findings, initially observed in melanoma, have also been confirmed in renal and breast cancers; (ii) we successfully implemented an original in vivo model of metastatic runaway in order to mimic what occurs in patients.”

Continue reading: DOI: https://doi.org/10.18632/oncotarget.28609

Correspondence to: Guilhem Bousquet

Email: guilhem.bousquet@aphp.fr 

Keywords: metastatic disease, PROM2, biomarker, tumor

growth models

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