Oncotarget: Prostate cancer and a possible link with schizophrenia

Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable and favorable disease prognosis respectively.

The following gene... continue reading >>

Oncotarget: Drug-resistant cells grow exponentially in metastatic prostate cancer

The cover for issue 1 of Oncotarget features Figure 2, "Results in clinical trials," published in "Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer" by Blagoev, et al. which reported that most metastatic cancers develop drug resistance during treatment and continue to grow, driven by a subpopulation of cancer cells unresponsive to the therapy being administered.

There is evidence that metastases are formed by phenotypically plastic... continue reading >>

Oncotarget: Altered glucuronidation signifies castration resistance in prostate cancer

Oncotarget published "Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer" which reported that Glucuronidation controls androgen levels in the prostate and the dysregulation of enzymes in this pathway is associated with castration resistant prostate cancer.

UDP-glucose dehydrogenase produces UDP-glucuronate, the essential precursor for glucuronidation, and its expression is elevated in prostate cancer. All pairs showed ... continue reading >>

Oncotarget: RNA expression differences between Black and White Americans

Oncotarget published "RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans" which reported that the authors examined RNA expression in both tumor and TAS of BA compared to WA.

After evaluating the geographical ancestry of each sample, preliminary analysis of their own RNA-seq data of 7 BA and 7 WA TAS revealed 1706 downregulated and 1844 upregulated genes in BA relative to WA PCa patients.

An assessment of published RNA-seq data of... continue reading >>

Oncotarget: Researchers identify a potential molecular trigger for invasiveness in prostate cancer cells

The cover for issue 58 of Oncotarget features Figure 2C, "Representative confocal imaging of PC-3U cells treated with TGFβ for the indicated time periods," from Gudey, et al.

ORCHARD PARK, New York - (Nov. 20, 2017) - A small protein modification can trigger the aggressive migratory and invasive properties of prostate cancer cells, according to new research published on the cover of Oncotarget. The findings give greater insight into how cancers can move from one location in the body to... continue reading >>

Interview with Marene Landström

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